Phase Ⅰ designs traditionally use the dose-limiting toxicity(DLT),a binary endpoint based on the first treatment cycle,......

In clinical trials and biomedicine studies,longitudinal data arise commonly and such that the longitudinal outcomes are ......

This paper concerns regression methodology to assess relationships between multi-dimensional response variables and cova......

Competing risks framework,where an individual fails due to multiple causes,is frequently available in biomedical studies......